منابع مشابه
Gsa-selective G protein antagonists
Suramin acts as a G protein inhibitor because it inhibits the rate-limiting step in activation of the Ga subunit, i.e., the exchange of GDP for GTP. Here, we have searched for analogues that are selective for Gsa. Two compounds have been identified: NF449 (4,4*,4(,4*(-[carbonyl-bis[imino-5,1,3benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3disulfonate) and NF503 (4,4*-[carbonylbis[imino-...
متن کاملG protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding.
A substance P (SP) analog, [D-Pro4,D-Trp7,9,10] SP4-11, is known to inhibit the actions of various structurally unrelated messenger molecules as well as SP. Our studies on the effects of this peptide on the regulation of purified G proteins by receptor showed that at least some of the biological effects of the peptide can be explained by the ability of the peptide to block the activation of G p...
متن کامل, a Variant of Stimulatory G Protein - Subunit ( Gs ) , Is a Distinct , Membrane - Anchored GNAS Product that Can Mimic Gs
Endocrine Unit (C.A., M.J.M., H.A.W.T., M.B.), Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; Department of Endodontics (C.A.), Center for Dental Sciences, Gülhane School of Medicine, 06018 Ankara, Turkey; Departments of Neurology (N.A., N.W.K., A.D.) and Pathology (N.W.K.), Boston University School of Medicine, Boston, Massachuse...
متن کامل[Selective muscarinic receptor antagonists].
3ubtypes of muscarmic receptors, first hypothesized by Birdsall et al. ~ to explain the anomalous binding of cholinergic agonists to brain receptors~ were later demonstrated with the seEective muscarinic antagonist, pirenzepine 2. Interestingly, the search for selective antagonists, which usually follows the acceptance of a concept, antedated by many years the notion of heterogeneity of rmecari...
متن کاملInteractions between G-protein-coupled receptors and periplakin: a selective means to regulate G-protein activation.
A substantial number of G-protein-coupled receptor-interacting proteins have been identified initially by the use of yeast two-hybrid screens. Using the C-terminal tail of both opioid receptors and the melanin concentrating hormone receptor-1 as bait, the actin and intermediate filament-binding protein periplakin was isolated. In each case, the site of interaction is within helix VIII of the re...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.1.346